2Two HLA-A2-restricted peptides from cyclin E1 and cyclin E2 elicit CTL that kill myeloid leukemia cell line
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چکیده
منابع مشابه
Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest...
متن کاملCyclin E1 regulates hematopoietic stem cell quiescence
Comment on: Campaner S, et al. Cell Cycle 2013; 12;3663–72; PMID:24091730; http://dx.doi.org/10.4161/cc.26584 Senthil Raja Jayapal and Philipp Kaldis; Institute of Molecular and Cell Biology (IMCB); A*STAR (Agency for Science, Technology and Research); Singapore, Republic of Singapore; National University of Singapore (NUS); Department of Biochemistry; Singapore, Republic of Singapore; *Email: ...
متن کاملBreak CDK2/Cyclin E1 Interface Allosterically with Small Peptides
Most inhibitors of Cyclin-dependent kinase 2 (CDK2) target its ATP-binding pocket. It is difficult, however, to use this pocket to design very specific inhibitors because this catalytic pocket is highly conserved in the protein family of CDKs. Here we report some short peptides targeting a noncatalytic pocket near the interface of the CDK2/Cyclin complex. Docking and molecular dynamics simulati...
متن کاملMHC recognition by hapten-specific HLA-A2-restricted CD8+ CTL.
T cell recognition by peptide-specific alphabeta TCRs involves not only recognition of the peptide, but also recognition of multiple molecular features on the surface of the MHC molecule to which the peptide has been bound. We have previously shown that TCRs that are specific for five different peptides presented by HLA-A2 recognize similar molecular features on the surface of the alpha1 and al...
متن کاملCytomegalovirus induces HLA-class-II-restricted alloreactivity in an acute myeloid leukemia cell line
Cytomegalovirus (HCMV) reactivation is found frequently after allogeneic hematopoietic stem cell transplantation (alloSCT) and is associated with an increased treatment-related mortality. Recent reports suggest a link between HCMV and a reduced risk of cancer progression in patients with acute leukemia or lymphoma after alloSCT. Here we show that HCMV can inhibit the proliferation of the acute ...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2003
ISSN: 1083-8791
DOI: 10.1016/s1083-8791(03)80003-4